NOT KNOWN FACTS ABOUT ABBV-CLS-484

Single-mobile RNAseq analyses of tumor-infiltrating immune cells verified activation of T cells and shown switching of myeloid-derived suppressor cells in direction of a proinflammatory phenotype, thus revealing a definite mechanism of action of ABBV-CLS-484 in contrast with PD-1 blockade. Our results show that PTPN2/N1 inhibitors have complementar